Effectiveness of endometrial scratching in infertility treatment with assisted reproductive technologies

Embryo implantation is a key factor limiting the effectiveness of assisted reproductive technologies, and depends on quality blastocyst susceptibility endometrium. Various methods treatment aimed at improving receptivity uterine mucosa, including endometrial scratching, have been proposed. At same time, main mechanisms underlying this intervention remain unclear. Moreover, optimal duration exposure to mucosa groups patients in which it can positive effect not determined. The study aims investigate evaluate local damage performed various times before embryo transfer program technologies women with without history failures based analysis scientific literature. Clinical studies, systematic reviews meta-analyses were studied PubMed, Embase, Cochrane Library, Web Science databases, Elsevier, Springer, Wiley publishers, eLibrary, Research Gate platforms, open sources educational segment Internet. literature search was conducted by keywords: damage, failures, receptivity, infertility. depth 20 years. scratching increasing include decidualization, development inflammatory reaction, as well improved synchronization between transferred preventing premature maturation Studies that showed mainly repeated luteal phase cycle preceding stimulation. work non-selective population non-standardized most cases, did reveal advantages scratching. In regard, additional qualitative randomized controlled trials large sample size clear identification for whom may benefit are required.